Document Type : Case Report
Authors
1
Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA
2
Dermatology Consultants P.A., Hialeah, Florida, USA
3
JAS Medical Management, Miramar, Florida, USA
4
College of Biomedical Sciences, Larkin University, Miami, Florida, USA
5
HCA Northside Hospital, USF Morsani College of Medicine, St Petersburg, Florida, USA
6
Department of Internal Medicine, MercyHealth GME Consortium, Rockford, Illinois, USA
10.22034/ncm.2023.418688.1138
Abstract
Background and Objectives: Our case presents an aggressive and resistant biological course, leading to a poor prognosis in a patient with mycosis fungoides, who underwent multiple therapies with no resolution, requiring aggressive chemotherapy due to systemic involvement.
Case Presentation: A 64-year-old Hispanic male presented to the dermatology clinic for evaluation of hardened, erythematous lesions distributed on his trunk and upper extremities with associated generalized pruritus. He stated the lesions have been present for about 2 years and have since grown in size. Pathology from punch biopsies take from the lesions confirmed. A diagnosis of mycosis fungoides. Topical glucocorticoids and systemic retinoid treatment were initiated, but after six months the disease progressed to involve lymph nodes. He underwent multiple rounds of radiation on advanced lesions. Patient was referred to an oncologist to continue treatment given the poor prognosis.
Discussion: Mycosis fungoides is a form T cell lymphoma that that is usually limited to the cutaneous tissue. A high expression of CD30+ lymphocytes in the epidermis is indicative of transformation into advanced large cell lymphoma, suggesting an aggressive clinical course and overall poor prognosis. Although mycosis fungoides is typically a low-grade, indolent malignancy our case has shown an aggressive and resistant biological course, leading to a poor prognosis.
Keywords
Main Subjects
)